OpCoBe

Monochrome single-channel fiber optic recording system.

The Monochrome Single Channel Fiber Photometry Recording System provides stable, real time detection of neural activity in targeted brain regions of laboratory animals. Using LED based excitation and optical fiber signal transmission, the system captures fluorescence changes from calcium sensitive probes and converts them into recordable signals for analysis. Compared with earlier designs, the LED upgrade delivers improved stability and longer operating life, making it a reliable solution for neuroscience research applications.

Monochromatic multi channel optical fiber recording system.

The multi channel fiber photometry system uses CMOS array imaging to measure fluorescence from each fiber in a multimode bundle in real time, enabling simultaneous multi channel recording. It supports optogenetic identification of specific cell types, records neural activity during natural movement, and allows observation of neural projection activity during complex animal behavior. The system includes a complete optical recording setup with hardware and analysis software, and is designed to be simple, stable, and easy to use.

Two color multichannel optical fiber photometry system.

The dual color multichannel fiber photometry system adds a 405 nm control channel to reduce noise and improve signal reliability. It couples two excitation wavelengths into the same optical fiber, delivers them to targeted brain regions, and captures the returning calcium signal fluorescence through the same fibers. Using time division multiplexing and CMOS array imaging, it measures fluorescence from each fiber in real time, enabling simultaneous multi channel recording.

Wireless Optical Genetics – Magnetic Field Edition.

This wireless optogenetic system is a fully implantable, ultra thin and lightweight probe for in vivo stimulation in freely moving animals. It uses a PDC control box for wireless one to many control, allowing batch optogenetic experiments in enclosed environments without batteries or tethering.

The system offers miniature LED probes with 470, 530, 590, and 650 nm wavelength options, optional probe lengths of 2 to 6 mm, and a very small, flexible design that is biologically compatible and stable for more than two months. It is suited for regulation of the brain, spine, and peripheral nervous system, with key advantages including being lightweight, implantable, battery free, and easy to fix in place.

It is also used by a range of major universities, hospitals, and research institutes in China.

Miniscope imaging system.

This system is used for in vivo calcium imaging in freely moving animals to study how neuronal circuits in different brain regions relate to behaviour. It enables real time observation of brain activation, neural projection activity during complex behaviours, calcium activity in deep brain and cortex, and changes in fluorescent cell migration in deep brain regions.

The platform includes components such as a miniature microscope, fixation plate, GRIN lens, CMOS sensor, image acquisition card, software, and steering gear. It records calcium signals from groups of neurons at single cell resolution, remains small and lightweight so it does not interfere with animal movement, and supports deep brain imaging through implanted GRIN lenses.

Its workflow involves expressing calcium indicators such as GCaMP6 through viral injection, implanting a GRIN lens, and then capturing fluorescence changes caused by increases in intracellular calcium during neural activity. These signals are converted into images by CMOS and analysed with software to link neural activity with behaviour.

Precision manual four-dimensional micromanipulator.

This micro manipulator is a precision positioning system designed for animal experiments that require highly accurate placement, such as electrophysiology and drug injection. It provides independent four dimensional adjustment, including XYZ movement with 13 mm travel and angle adjustment from 0° to 90°, allowing flexible and stable positioning.

It uses precision linear guides, a fine toothed micrometer head, and spring reset to ensure smooth control, minimal clearance, and high stability. With accuracy down to 5 microns and resolution of 2 microns, it is well suited for delicate experimental work. When paired with a head fixation system, it can also form a complete insulated stereotaxic setup for small animals.

Microlens embedded collimator.

This instrument is a miniscope lens implantation helper designed to improve precision during placement of miniature endoscopes and cameras in brain research. It allows five dimensional adjustment in XYZ and aβ, so the miniscope can be accurately aligned with the upper plane of the endoscope and then lowered together while the target area is monitored in real time.

It supports electric micro manipulation with controllable descent speed and distance, enabling automated implantation of tiny miniscopes. The system can also be upgraded to fully automatic lens embedding, supports a range of microlens gripper sizes, and can be customised for miniature cameras from different manufacturers. Its compact design and universal 8 mm vertical lever make it easy to integrate with locator systems.